Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
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چکیده
منابع مشابه
Factors Influencing the Hepatic Response to Drugs
The hepatic microsomal enzymd system plays an outstanding role in the metabolism and detoxication of most drugs" 2, whereas the frequency of drug-induced liver disease increases steadily as 'a penalty for progress'3. Two main questions therefore arise: (1) Why do some drugs, ie, by which cellular mechanism(s), provoke side effects upon the liver, and (2) how might we predict them? The purpose o...
متن کاملGenetic predictors of interindividual variability in hepatic CYP3A4 expression.
Variability in hepatic CYP3A4 cannot be explained by common CYP3A4 coding variants. We previously identified polymorphisms in pregnane X receptor (PXR) and ATP-binding cassette subfamily B member 1 (ABCB1) associated with CYP3A4 mRNA levels in small cohorts of human livers. However, the relative contributions of these genetic variations or of polymorphisms in other CYP3A4 regulators to variable...
متن کاملA new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.
BACKGROUND Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates its use in preventing rejection after kidney transplantation. This variability might be caused by genetic polymorphisms in metabolizing enzymes. METHODS We used TaqMan analyses to evaluate the impact of a newly discovered CYP3A4 (cytochrome...
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Induction of cytochrome P450 3A4 (CYP3A4) is determined typically by employing primary culture of human hepatocytes and measuring CYP3A4 mRNA, protein and microsomal activity. Recently a pregnane X receptor (PXR) reporter gene assay was established to screen CYP3A4 inducers. To evaluate results from the PXR reporter gene assay with those from the aforementioned conventional assays, 14 drugs wer...
متن کاملTRANSLATIONAL PHYSIOLOGY Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy
Kim, Sara, Choong H. Kim, and Nosratola D. Vaziri. Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy. Am J Physiol Endocrinol Metab 288: E813–E817, 2005. First published December 7, 2004; doi:10.1152/ ajpendo.00266.2004.—Nephrotic syndrome (N-S) is associated with elevated plasma concentration and impaired clearance of VLDL, chylomicrons (CM)...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2010
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2010.28